Keywords
Abstract
The aim of the study – based on research of electrocardiography to evaluate cardioprotective effect and features of action of new potential drug «Hypertril» under chronic heart failure (CHF) modeling.
The experimental part of the work was performed on 70 outbred white rats weighing 190–220 g. Chronic heart failure was modeled by the administration of doxorubicin (intraperitoneally at a cumulative dose of 15 mg/kg, divided into 6 injections over 14 days). Study drugs – Hypertril was administered once
a day intragastrically at a dose of 3,5 mg/kg for 45 days; metoprolol succinate – according to the same scheme at a dose of 15 mg/kg. The presence of CHF was confirmed by electrocardiography using a CardioCom-2000 plus computer analyzer (XAI-medika, Ukraine).
Modeling CHF in experimental animals led to elevation of the ST segment above the isoline by about 0,1 mV (14,3 times), to an increase in the contractile function of the ventricles (increase by 36 % of the amplitude of the R wave) in combination with an extension of the phase of their depolarization (QRS
complex) by 11,5 % and repolarization (T wave) by 9,5 % relative to the duration of the cardiac cycle, a decrease in the spectral power of the heart rate TPW and an increase in the stress index SI by 2,7 times, to a decrease in the time of electric diastole to (4,2 ± 0,2) ms (11,6 times). After metoprolol administration the duration of repolarization was more than 40 % higher than that in intact rats and untreated animals with CHF, and it was 50 % of the RR cardiac cycle duration. The duration of electrical diastole TR, although it increased 2 times compared with animals with CHF, but it remained 5 times shorter than in intact animals. After Hypertril administration the ECG showed normalization of the amplitude of the ventricular R wave and normalization of the amplitude of the T repolarization wave, a significant decrease in the amplitude of the ST segment above the isoline – 4 times compared with the control group and 2,5 times compared with animals treated with metoprolol, normalization of the duration of the QRS complex and the T wave, as well as the TR interval. This indicates that course administration of Hypertril prevents the formation of diastolic dysfunction.
The result obtained are experimental substantiation of the prospects for further research of the potential drug Hypertril in the form of tablets.