Keywords
Abstract
This work is dedicated to pharmacokinetic studies of elimination processes of new coordination germanium compound Cerebrogerm (ferum bis(cytrato)germanatе), which shows pronounced cerebroprotective activity on the model of isolated craniocerebral trauma (ICT).
Experiments were conducted on ICT model, which was recreated in rats by application of a strike dosed by strength and oriented by localization with a falling 45 g object on parietal skull part of rats under light ether anesthesia. ICT, which is being modeled, matches moderate form of brain injury.
There were studied variety of parameters, which characterize elimination process: period of half elimination (t1/2,el, hour), elimination rate constant (Кel, hour-1), general clearance (ClТ, ml/min), average residence time in organism (MRT, hour) in rats with ICT in comparison to healthy animals (norm). Comparative analysis of obtained pharmacokinetic parameters of Cerebrogerm, which characterize the process of it’s elimination in normal and ICT condition rats convincingly (р < 0,050–0,001) indicates deceleration of processes of biotransformation and excretions of potential cerebroprotector in early stages of post traumatic period of ICT.
Most intensive changes occur in period of half elimination, elimination rate constant and general clearance.
Reasons of changes of parameters, which characterize elimination of potential cerebroprotector on experimental models of traumatic brain disorder, are discussed.
The data obtained can be an experimental basis for necessity of additional pharmacological support of metabolic-excretion organs (kidneys, liver) which will contribute to increase in effectiveness of pharmacotherapy of consequences of ICT in early post traumatic period.