Study of the effect of aqueous extract and tincture from Cetraria Islandica (L.) on thyroid function and protein metabolism in experimental hypothyroidism

Abstract

This work was aimed to study the effect of aqueous extract and 30 % tincture of thallus from Cetraria islandica (L.) on the level of iodine-containing thyroid hormones and pituitary thyroid-stimulating hormone, as well as on protein metabolism under the model of mercazolil-induced hypothyroidism in rats.
To achieve this goal, the levels of thyroxine, triiodothyronine and thyroid-stimulating hormone were determined by enzyme-linked immunosorbent assay using test systems. A photocolorimetric method was used to determine biochemical parameters (total protein, albumin, urea, creatinine).
Studies have shown that the course use of aqueous extract and 30 % tinctures from thallus of Cetraria islandica (L.) under merkazolil-induced hypothyroidism leads to a probable increase in thyroxine and triiodothyronine, reducing the level of thyroid-stimulating hormone. The positive effect of aqueous extract
and 30 % tinctures of Cetraria islandica (L.) thallus on protein metabolism is confirmed by a decrease of urea and creatinine levels in blood of experimental animals.
Thus, the aqueous extract and 30 % tinctures from Cetraria islandica (L.) thallus can be recommended for further study as promising medicines for the therapy of thyroid gland hypofunction and protein metabolism violations.