Keywords
Abstract
The hepatobiliary system diseases are significantly widespread among the working population, and one of the areas of their pharmacotherapy is the use hepatotropic herbal preparations. In particular, common tansy has long been known for its hepatotropic properties and is still used in folk medicine.
The aim of the study – screening study of choleretic and cholekinetic effects of thick extract of flowers of common tansy (Tanacetum vulgare L.) on healthy animals.
The following parameters were determined: the volume of excreted bile within 3 hours with hourly registration after the introduction of the studied extract and reference drugs by sampling bile from a test tube, the rate of bile secretion was also calculated (mg/min/100 g of body weight).
The study and analysis of the experimental data obtained were carried out in comparison with the preparations of the plant group choleretic and synthetic cholelitholytic agents – the collection of Phytohepatol and the preparation Ursofalk. The study showed that the substance under study has a stimulating
effect on these processes in all doses that were studied during the experiment. Of the several studied doses of a thick extract from the common tansy flowers, one conditionally effective was chosen, that is, the minimum dose of a substance that is capable of providing the maximum therapeutic effect. It was also found that the conditionally effective dose 100 mg/kg exhibits a stimulating effect on the formation and secretion of bile during the entire observation period of the experiment.
A reliable stimulating effect of a thick extract from the tansy flowers on the processes of choleresis and cholekinesis in healthy animals has been established. Also, during the screening study, a conditionally effective dose of a thick extract from the tansy flowers was established, which is characterized by a significant choleretic activity and its duration.