Keywords
Abstract
The use of herbal medicines today is becoming especially widespread. Modern research on the study of the pharmacological effects of medicinal plant raw material and its biologically active components allows it's reasonably use in the development of complex herbal medicines for the pharmacotherapy of
various diseases, in particular the liver. Such medicines have a number of the known advantages over synthetic agents. A wide range of pharmacological actions makes it possible to comprehensively affect various manifestations of liver pathologies, and also reduces the load on the diseased organ by reducing
the amount of simultaneous administration of several drugs.
The aim of the study – an experimental investigation of anti-inflammatory activity of the combined herbal agent «Pancreo-Plant». The experiments were carried out on male and female rats weighing 180–200 g. The study of the antiinflammatory effect of the herbal medicine «Pancreo-Plant» was performed on the models of carrageenaninduced edema and zymosan-induced edema of the rat's paw. The activity of the drugs was assessed by the ability to reduce edema compared to the control group.
During the experiment it was found that Pancreo-Plant exhibited the greatest anti-inflammatory activity in the first two hours of inflammation, confirming its high anti-lipoxygenase activity. It should be noted that due to the anti-inflammatory effect in the first hours of acute zymosan-induced inflammation this medicine exceeded the activity of sodium diclofenac and quercetin, the known agent with the proven antilipoxygenase activity.
It was shown, that Pancreo-Plant in the dose range of 36–90 mg/kg has the anti-inflammatory activity on the model of acute carrageenan-induced edema. The optimal dose (72 mg/kg) has been selected. In conditions of zymosan-induced edema potent anti-inflammatory effect of Pancreo-Plant in the dose of 72
mg/kg exceeding the effectiveness of the reference drugs diclofenac sodium and quercetin has been confirmed. Exactly this dose of Pancreo-Plant was recomended for further studies of the pharmacological effects of the herbal medicine in conditions of a liver pathology.