Keywords
Abstract
The most promising in the treatment and prevention of acute rhinosinusitis (ARS) is the use of сomplex drugs that reduce the economic costs and increase the compliance of therapy, decrease the severity of the disease, minimize its duration, prevent complications, as well as chronic pathology.
The aim of study was to evaluate an effectiveness of the combination of 3 % glycerol solution with plant tannins (Humerus Sinusitis) in the complex treatment of ARS.
The current stage of the study involved 64 patients (men and women) aged 18–60 years with a diagnosis of ICD-10 J01 – acute sinusitis. All patients underwent examination and inpatient treatment in health care facilities of the city of Dnipro for the period 2020–2021 and provided informed written consent to participate in the study.
The main observation group (32 patients) received standard drug therapy using Humer Sinusitis as an elimination-irrigation agent, comparison group I (13 patients) – isotonic nasal spray, comparison group II (19 patients) – hypertonic nasal spray.
The results of rhinoscopic examination showed that after the end of therapy in 25 % (8 of 32) patients in the group using the combined drug Humer Sinusitis as an elimination – irrigation agent mucosal hyperemia and edema were observed, while in reference groups I (isotonic nasal spray) and II (hypertonic nasal spray) in 53.8 % (7 of 13) and 47.4 % (9 of 19) patients, respectively.
A comparative analysis of rhinomanometry in patients with acute rhinosinusitis treated with different regimens showed a more significant dynamics of changes in Total volume flow (TVF) and Total aerodynamic drag (TAD) in patients of the group using 3 % glycerol solution enriched with plant extracts. In this group, the value of the TVF that increased of the end of treatment by 46.3 % (p < 0,01) was restored almost to the corresponding parameters of the physiological norm, while in the the reference groups I and II it increased only by 30.2 % (p > 0.05) and 36.5 % (p < 0.05) respectively as to parameters before
treatment. In particular, in patients with irrigation therapy using 3 % glycerol solution enriched in specific proanthocyanidins, there was a statistically significant difference in cytosis, absolute neutrophil content, the proportion of destructive phagocytes and phagocytosis of autoflora compared to reference group I and autoflora – with reference group II.
These changes of the of nasal secretion cytogram parameters indicate a significant weakening of the inflammatory process and a positive effect on the adaptive immunity of the treatment by the combined drug Humer Sinusitis as an elimination and irrigation agent.
Thus, the clinical effectiveness of elimination and irrigation therapy using Humer Sinusitis in ARS is due to improved mucociliary clearance of the upper respiratory mucosa, reduced inflammation and correction of local immune status.