Keywords
Abstract
An increase of alcoholic beverages consumption in Ukraine and in the world is the reason for an increase of alcohol-related damage to the heart, brain, liver, etc. Alcoholic cardiomyopathy (ACMP) is accompanied by the development of encephalopathy and requires specific means of correction. The use of drugs with polytropic pharmacological properties in the treatment of such comorbid conditions is currently promising. The purpose of the study is to research the effect of vinboron, in comparison with mildronate and citicoline, on cognitive abilities and memory of rats with experimental alcoholic cardiomyopathy. Experiments were conducted on 50 nonlinear male rats weighing 190–210 g. Experimental toxic alcoholic damage to the heart was modeled by intragastric administration of 50 % ethanol (6 g/kg) to rats for 9 weeks. Animals were divided into 5 groups: 1st group – control; 2nd group – animals with ACMP without treatment; the 3rd, 4th, and 5th groups are rats with ACMP treated for 14 days with vinboron (5 mg/kg/day, i. m.), mildronate (50 mg/kg/day, i. m.) and citicoline (250 mg/kg/day intravenously) respectively. All drugs were studied in therapeutically effective doses borrowed from the literature. Locomotor abilities and emotional state of rats were studied using the «Open field» test. The method of new objects recognizing was used to study the functions of working memory. Mnestic processes were studied by the passive avoidance test. In the course of the study, it was found that all proposed drugs during the course therapy (14 days) of rats with ACMP contributed to the reduction of neurological and cognitive deficits in the animals. This was manifested by an improvement of «Open field» test parameters, an increase in the percentage of trained animals when conducting the passive avoidance compared to animals without treatment (р ≤ 0.05). Vinborone at a dose of 5 mg/kg was practically comparable to citicoline (250 mg/kg) and somewhat superior to mildronate in its ability to improve the dynamics of cognitive and memory functions in rats with ACMP. The data obtained make it possible to recommend vinborone use as drug with pleiotropic action for the correction of cognitive disorders under cardiovascular pathology, in particular, an alcoholic cardiomyopathy.