Keywords
Abstract
The results of drug safety assessment of the novel latanoprost liposomal composition with a hypotensive influence in ocular hypertention at different methods of application are presented. With instillation and subconjunctival administration the latanoprost liposomal composition doesn’t have a dangerous effect on the state and structure of a conjunctival-limbal areas of the rabbits eye according to ophtalmoscopic and visual examination, optical coherent tomography and eye pressure control. With single intravenous injection of the composition there is no negative effect on the dynamics of body weight, the mass of internal organs and behavioral activity of mice. Also, alterative changes, hemocirculatory disorders, inflammatory reaction and sings of dysregenerаtive processes in organs were not identified. So, in acute and chronic designed studies with different methods of application the ophthalmic safety and the absence of systemic toxic impact were established for the latanoprost liposomal composition as a potential drug for the treatment of ocular hypertension with high compliance.