Keywords
Abstract
Drug interference in laboratory tests (Drug Laboratory Tests Interference, DLTI) in vivo and/or in vitro is an important but understudied medical problem.
The result of such interventions can be late establishment and/or establishment of a false diagnosis, appointment of unnecessary additional tests or therapy, additional monitoring of treatment, harm to patients, increase the financial burden on health care, physical burden on doctors and specialists in laboratory diagnostics.
The analysis of the state of the problem shows that the main source of information regarding physiological DLTIs is the instructions for the medical use of drugs, analytical – spontaneous reports.
The available information is not comprehensive, it concerns mainly single-component drugs, is fragmentary, insufficiently documented; there is no unified system for collecting and analyzing messages about DLTI; modern tools for their assessment and clinical decision-making algorithms have not been developed.
Ways to solve the problem are seen in conducting systematic studies of DLTI, including fixed combinations or simultaneous use of several drugs, elucidating the mechanisms of detected interferences, developing approaches to obtaining and verifying information, creating information expert systems to support clinical decisions.
The questions of revising educational programs in medical institutions, in particular regarding clinical laboratory research, their selection and interpretation of results, as well as the training of expert consultants in laboratory diagnostics, are also considered relevant.