Drug dosage forms of non-steroid anti-inflammatory agents: problems and prospects (literature review)

Abstract

Nonsteroidal anti-inflammatory drugs are most commonly used in clinical practice. One of the methods of increasing the «benefit/risk» ratio for the patients is creation special drugs dosage forms that take into account its pharmacodynamics, pharmacokinetics and toxicity.

The literature review presents information about nonsteroidal anti-inflammatory drugs and various approaches to creating oral dosage forms with modified release of nonsteroidal anti-inflammatory drugs. Approaches to development injection forms are also presented, taking into account the moderate/poor solubility of active pharmaceutical ingredients of this pharmacological group. Biologically compatible poly- mers of synthetic and natural origin used as drug excipients are considered. Various methods used to obtain granular, tablet, capsule and other dosage forms of non-steroidal anti-inflammatory drugs are discussed. The characteristics of ready-made microparticles with non-steroidal anti-inflammatory agents encapsulated in them are given.