Keywords
Abstract
The article presents the results of the study of a new anti-allergic combined herbal remedy under the conditions of experimental allergic contact dermatitis. The search for new original drugs with antiallergic effect remains an urgent issue of modern medicine and pharmacy in connection with the significant spread of allergic diseases among the population. Scientists of the National Pharmaceutical University have developed a new anti-allergic combined herbal medicines (ACHM) containing standardized extracts of a series of three-parted grass, flower buds, hawthorn leaves and flowers.
The purpose of the study was to evaluate the effect of ACHM on the histological structure of the skin of Guinea pigs with the model of allergic contact dermatitis.
Allergic contact dermatitis was induced by applying a 5% alcohol-acetone solution of 2,4-dinitrochlo- robenzene (DNHB) to the skin of Guinea pigs. ACHM was administered at a dose of 30 mg/kg, the comparison drug Desloratadine was administered at a dose of 0.30 mg/kg, the comparison drug Tesalin was administered at a dose of 7.2 mg/kg. All drugs were administered intragastrically once a day for 10 days. Their effects were evaluated by the histological structure of the skin of Guinea pigs with the model of allergic contact dermatitis.
It was established that the new ACHM at a dose of 30 mg/kg has a significant antiallergic effect under the conditions of allergic contact dermatitis in Guinea pigs. In terms of the expressiveness of the positive effect on the histo structure of the skin of Guinea pigs with allergic contact dermatitis, products based on medicinal plants, ACHM and Tesalin, were somewhat inferior to the antihistamine drug Desloratadine. Antiallergic effect of ACHM exceeds the effectiveness of the comparison drug Tesalin.
Thus, ACHM exerts an anti-allergic effect, which was established by a positive influence on the histological structure of the skin of Guinea pigs with allergic contact dermatitis model.