Keywords
Abstract
Damage to the pancreas caused by drugs is registered more and more every year. Medicinal plant raw materials with antioxidant and cytoprotective effects can be considered a promising object for reducing the toxic effect of some drugs on the pancreas.
The aim of the study was to evaluate the effect of marigold Tagetes Patula L. herb extract on the histostructure of the pancreas under experimental streptozotocin-induced injury.
Experimental streptozotocin-induced injury was modeled by a single intraperitoneal injection of streptozotocin at a dose of 55 mg/kg to rats weighing 180–220 g. Dry extract of the marigold herb (EМР) was administered intragastrically at a dose of 25 mg/kg in the therapeutic and preventive mode.
It has been established that under the conditions of the development of experimental streptozotocininduced pancreatic injury, EМР exerts a powerful organoprotective effect, which is evidenced by the positive dynamics of structural changes in the islet apparatus, a decrease in destructively and dystrophically changed cells and an increase in functionally complete insulinocytes. In addition, the studied extract exhibits an anti-inflammatory effect, significantly reducing signs of insulitis and inflammatory reaction in the interacinar tissue. Morphometrically, in the group of animals that received EMP compared to untreated animals, an increase in the number of pancreatic islets in micro preparations, the content of beta cells and alpha cells, as well as an increase in the functional index and restoration of the percentage distribution of islets by classes were found.
Thus, under the conditions of streptozotocin-induced injury, the administration of EMP to rats at a dose of 25 mg/kg intragastrically in the therapeutic and preventive mode has a protective effect on the insular apparatus of pancreas.