Keywords
Abstract
Violation of hemodynamics and microcirculation in the tissues of the prostate gland due to endothelial dysfunction is one of the leading pathogenetic mechanisms of the development of chronic prostatitis. Therefore, the therapeutic effectiveness of modern prostate protectors is largely determined by their ability to correct such pathological changes in the tissues of the prostate gland during inflammation.
The aim of the study was comparative evaluation of prostate protectors (Tribestan and Prostatylen) on thel state of the vascular endothelium in the model of chronic prostatitis in rats.
The model of chronic prostatitis in rats was reproduced by a single rectal injection of 1.0 ml of a mixture of turpentine and 10% dimexide in a ratio of 1:4. The drugs, Tribestan and Prostatylen, were used once daily for 30 days after the administration of phlogogen to the animals.
Studies have shown that Tribestan in a conditionally therapeutic dose of 60 mg/kg intragastrically and Prostatylen in a dose of 200 μl/kg intraperitoneally after course administration for 30 days to rats under model of chronic turpentine prostatitis with varying effectiveness stabilize the content of S-NO and endothelin-1 in blood and correct disorders of the vascular endothelium by reducing the imbalance of eNO-synthase and iNO-synthase activity. At the same time, the endothelium-protective effect of Tribestan under the given conditions of the experiment turned out to be higher.