Keywords
Abstract
Lately, in search of new anti-inflammatory drugs, liposomal drug Lipoflavon, which contains natural flavonoid – 3,3’,4’,5,7-pentaxiflavon (quercetin), is of considerable interest.
The aim of the study – to research anti-inflammatory activity of the liposomal form of quercetin (Lipoflavon) in different models of exudative inflammation.
Studies of anti-inflammatory activity of liposomal form of quercetin – Lipoflavon were conducted on models of exudative inflammation in paws of mice, caused by subplantar injection of various flogogenic agents.
The data obtained showed, that liposomal form of quercetin – Lipoflavon in the dose range of 3.8–15.2 mg/kg (for quercetin) statistically reliably inhibits edema caused by carrageenan with values of (-37,09)% to (-63,43)%. Experimental inflammation, caused by other flogogenic agent – histamine, also demonstrates antiexudative effect of Lipoflavon in boundaries from (-27,61)% to (-32,73)%. In model of serotonine edema positive dynamic of anti-inflammatory action of liposomal form of quercetin is still present and is in boundaries of (-17,95)% to (-32,00)%.
Thus, liposomal form of quercetin Lipoflavon shows antiexudative activity comparable to that of sodium diclofenac or exceeds it.