Keywords
Abstract
The non-specific effect of antitumor chemotherapy on the tissue adjacent to the tumor itself can worsen the organism’s state additionally to the consequences of neoplastic process development and even may have a decisive role in the survival of the whole organism. Therefore, it is relevant to conduct parallel studies of the effect of new antitumor agents at the stage of preclinical trials on both tumors and tissues that are not affected by neoplastic changes in order to further optimization of chemotherapy. Objective: to study the effect of Ifitinib on DNA, RNA, chromatin proteins, DNA fragmentation processes, the content of non-protein and protein-associated SH-groups in Guerin's carcinoma and unchanged uterine tissues. A study was carried out on white Wistar female rats. Animals were randomized into 3 groups of 6 animals each: 1 – intact rats; 2 – negative control (Guerin's carcinoma) 3 – Guerin's carcinoma + 29.93 mg / kg Ifitinib. A study of Ifitinib effects on DNA, RNA, chromatin proteins, DNA fragmentation processes, the content of non-protein and protein-associated SH groups in Guerin's carcinoma and unchanged uterine tissues showed that this drug significantly changed the majority of the studied parameters both in comparison with intact animals and with Guerin's carcinoma without treatment. Moreover, the specificity of Ifitinib influence on tumor cells was most pronounced in the case of DNA fragmentation and changes in the content of non-protein and protein-associated SH-groups.