The Hedgehog signaling pathway: from mechanisms of transduction to the research of antitumor drugs

Abstract

The article provides an overview of contemporary data dealing with the Hedgehog signaling pathway, including at the malignant growth. There were also considered the main links of mitogenic signals transduction as the targets for searching of antitumor drugs. The first successes in this direction were noted, namely drugs and substances with antitumor activity (Wismodegib, Sonidegib, GANT 58, GANT 61 et al.)