Keywords
Abstract
Canephron® H is a popular drug for the treatment of urogenital diseases. One of its key effects is antiinflammatory, which has been shown in a number of studies. The pathogenesis of CKD (chronic kidney disease) is associated with inflammation, so searching for effective anti-inflammatory drugs is relevant.
Since the studied spectrum of the drug effectiveness is based only on some nosologies from the group of CKD, it is advisable to study the nuances of the mechanisms of anti-inflammatory action of the standardized herbal composition BNO 2103, which is an active ingredient of Canephron® H. Positive results
may be the substantiation of expanding the range of applications of BNO 2103.
The aim of the study – to research the anti-inflammatory properties of the standardized herbal composition BNO 2103 on models of paw оedema in rats caused by various phlogogens (carrageenan and prostaglandin E2).
The experimental study was carried out on 60 male white outbred rats weighing 150–200 g, which were divided into 2 series of 30 animals, each series included 3 groups. Inflammation of the paw was modeled using subplantar injection of phlogogens – carrageenan and prostaglandin E2. The test agent and the reference drug, diclofenac sodium, were administered intragastrically once. Observation, fixation of the edema volume and assessment of anti-inflammatory activity occurred 0.5, 1, 2 and 3 hours after the introduction of carrageenan and 0.5, 1 and 2 hours after the introduction of prostaglandin E2.
Composition BNO 2103 showed an antiexudative effect in the carrageenan edema model, according to which, however, it was inferior to the reference drug diclofenac sodium, which is a non-selective COX inhibitor. In the model of prostaglandin edema, it showed an antiexudative effect no worse than the
comparator. Composition BNO 2103 showed the ability to inhibit the cyclooxygenase pathway of the conversion of arachidonic acid and the formation of inflammatory mediators and demonstrated a significant antiprostaglandin effect.
Thus, the standardized herbal composition BNO 2103 has a significant anti-inflammatory effect, exerting an inhibitory effect on exudative inflammation caused by various phlogogens (carrageenin, prostaglandin E2), suppressing the cyclooxygenase pathway of arachidonic acid conversion, which is most
likely due to the presence of flavonoids, essential oils and phenolic substances in the composition. This allows us to consider BNO 2103 as a promising antiphlogistic for the treatment of inflammatory kidney diseases.