Keywords
Abstract
The aim of the study – determination of the metals (Cu, Fe, Zn) content by inductively coupled plasma atomic emission spectrometry (ICP-OES) in pharmaceutical raw materials, medicines, medicine packa- ging material and dietary supplement. The samples were submitted for testing to the state research labora- tory for quality control of medicinal products to verify compliance with the requirements of regulatory documentation (RD).
The concentrations of Cu, Fe, Zn were determined by inductively coupled plasma atomic emission spectrometry on an Agilent 5800 ICP-OES optical emission spectrometer. Measurements of the metal content were performed by comparing the emissions of the studied solutions with the emissions of stan- dard solutions at wavelengths: Cu 327,395 nm, Fe 238,204 nm, Zn 213,857 nm. Pharmaceutical raw materials (ascorbic acid, sodium ascorbate, sodium sulfite, activated carbon), anti-inflammatory and antidiabetic drugs, medicine packaging material and dietary supplement were used as samples for research.
The content of metals was measured in 37 samples (Cu – 19 samples, Fe – 4 samples, Zn – 32 sam- ples). Concentrations above the instrument detection limits were recorded for Сu (89,5% of the tested samples), for Fe and Zn (100% of the tested samples).
In conclusion, the content of Cu and Fe in pharmaceutical raw materials, medicines, packaging of phar- maceutical products meets the requirements of regulatory documents in 100% of the samples. The con- tent of Zn complies with the requirements of regulatory documents in 96,9% of the samples (zinc content